CircHOMER1, which is produced by the HOMER1 gene, is highly intriguing because the HOMER1 protein links neural channels and receptors that the Aβ protein in the AD brain, and circHOMER1, was found to be significantly associated with AD diagnosis, clinical neurological staging, and dementia severity (Beylerli et al., 2024). The gene discussed is HOMER1; the disease is Alzheimer disease.