So far, over 70 molecules have been found in LBs formation but still, α-synuclein (α-syn) is considered a major component of LBs and it is now established that α-synuclein plays a significant role in LBs in both hereditary and sporadic PD, and its higher seeding kinetics can exhibit a unique role in perturbations of proteomics profiles of mitochondria and lipid metabolism (Kon et al., 2024). The gene discussed is SNCA; the disease is Parkinson disease.