UBE2A and Alzheimer disease: For example, CDR1 was found to be downregulated in AD sporadic patients, which may upregulate the expression of miR-7 and lead to ubiquitin-conjugating enzyme E2A (UBE2A) depletion which normally coordinated the removal and degradation of damaged and amyloid-containing proteins by 26S proteasomes (Fagan et al., 2007; Zhao et al., 2016; Shao et al., 2023).