circ-Pank1 by sequestering miR-7a-5p upregulate the expression of α-synuclein (α-syn), so far, circRNA profiling in both PD and healthy controls has identified a large number of differentially expressed (DE-circRNAs) that accumulate with aging in the brain and are associated with PD pathology by influencing the stability and transport of miRNAs, impacting the expression of α-synuclein (α-Syn), oxidative stress, aberrant mRNA transcription, cell death, and autophagy. This evidence concerns the gene PANK1 and Parkinson disease.