It has been observed that PD patients have lower levels of miR-7 in the SN region, which is associated with a higher accumulation of α-Syn in LBs, since the binding of miR-7 to the 3′UTR of α-syn directly inhibits its expression, indicating that miR-7 downregulation may play a role in α-syn aggregation, therefore upregulation of other circRNAs targeting miR-7 such as cirs-7 or circ-SNCA hosted by the SNCA gene which encodes α-syn protein can play a regulating role in the enrichment pattern of nucleoprotein in role in PD (Liu et al., 2022). Here, SNCA is linked to Parkinson disease.