Or they can help the proteins degradation by binding to specific RBPs, for example, circDNMT1 can help the nuclear translocation of the transcription factor TP53 (tumor protein P53), and RBP AUF1 (HNRNPD, heterogeneous nuclear ribonucleoprotein D) proteins in breast cancer (Du et al., 2018) (Figure 1). The gene discussed is HNRNPD; the disease is breast cancer.