The development of Aβ-42 plaques, neurofibrillary tangles (NFTs) made of hyperphosphorylated tau protein, and neuroinflammation brought on by the activation of microglia cells are the main pathological features of AD (Congdon and Sigurdsson, 2018; Bălaşa et al., 2020). This evidence concerns the gene MAPT and Alzheimer disease.