Additionally, tumor-infiltrating macrophages (CD11b+F4/80+) showed distinct immunophenotypic changes: M2-like (CD11b+F4/80+/CD206+/CD86−) macrophages decreased from 27.07 ± 2.72% (1,25(OH)2D3) to 15.88 ± 0.78% (combination; p < 0.01); and M1-like (CD11b+F4/80+/CD86+/CD206−) macrophages increased from 10.51 ± 2.50% (1,25(OH)2D3) to 25.96 ± 3.72% (combination; p < 0.001). The gene discussed is ITGAM; the disease is neoplasm.