Interestingly, binding of miR-7 seems to actively mediate the circularization of Cdr1-as (Belter et al., 2022), while loss of Cdr1-as leads to miR-7 destabilization and alters excitatory synaptic transmission, driving schizophrenia-associated behaviours (Piwecka et al., 2017). Here, CDR1 is linked to schizophrenia.