Subsequently, Iparraguirre and colleagues detected 406 differentially expressed circRNAs through a microarray analysis on peripheral blood leucocytes of four RR-MS patients and four healthy controls; two downregulated circRNAs, both deriving from the ANXA2 host gene, were validated in an independent cohort of 20 RR-MS patients and 18 healthy controls (Iparraguirre et al., 2017). The gene discussed is ANXA2; the disease is myeloid sarcoma.