These observations raised the possibility that some of the changes in circRNA expression in the AD brain might reflect the response to oTau toxicity, consistent with Cervera-Carles et al., who noted similar responses of circRNAs between FTD-tau (but not FTD-TDP-43) and AD (Cervera-Carles et al., 2020). This evidence concerns the gene MAPT and Alzheimer disease.