The key kinase of the BCR signal transduction pathway, BTK, is reversibly or irreversibly occupied by the binding of BTKi at the Cys481 residue and induces the alteration of the downstream PI3K/Akt, MAPK, and NF-κB pathways, potentially leading to the development of hypertension (Gallo and Savoia, 2024). The gene discussed is NFKB1; the disease is hypertensive disorder.