It encompasses a combination of asthma, chronic rhinosinusitis (CRS) with nasal polyps, and acute upper and lower respiratory reactions that occur following the ingestion of aspirin (acetylsalicylic acid, ASA) and other cyclooxygenase-1 (COX-1) inhibitory non-steroidal anti-inflammatory drugs (NSAIDs). Here, PTGS1 is linked to chronic rhinosinusitis.