Compared with the MOD group, the TGF-β/Smad2/SMAD3 pathway was significantly inhibited after DMDD intervention, and liver fibrosis indices COL1A1, α-SMA, and TIMP1 were significantly downregulated, while bile acid metabolism of CYP7A1, CPY8B1, CYP27A1, BSEP, MRP2, and NTCP were significantly upregulated (Figure 3D). This evidence concerns the gene SMAD3 and Hepatic fibrosis.