A second cluster (ELF2, ETS1, FOXO1, ERG, TAL1, FOXO3, FOXJ3, EBF1, and ZEB1) includes TFs regulating a diverse set of biological processes, including the transcriptional misregulation in cancer KEGG pathway and the KEGG prostate cancer pathway (Fig. 3C). This evidence concerns the gene FOXO1 and Familial prostate cancer.