There were commonly increased proangiogenic factors, including the VEGF-signaling pathway (186, 187), total and active membrane-type matrix metalloproteinase 1 (188), and cognate succinate receptors (189) in GDM placenta, but there was a reduction of anti-angiogenic receptor UNC5b in GDM HUVECs (190). The gene discussed is MMP14; the disease is gestational diabetes.