The conversion of glucose-6-phosphate (G6P) to free glucose, catalyzed by G6Pase-α, is a key step in releasing glucose from the liver into the bloodstream; the absence of G6Pase-α causes patients with GSDIa to suffer from serious and potentially life-threatening episodes of hypoglycemia.5,6. This evidence concerns the gene G6PC1 and Hypoglycemia.