KEGG analysis revealed dysregulations in critical pathways, including Pathways in Cancer, MAPK signaling, PI3K-Akt signaling, mTOR signaling, NF-κB signaling, cellular senescence and p53 signaling, which are integral to cell survival, proliferation, immune response, and apoptosis Pathways related to autophagy and cellular senescence were also notably affected, emphasizing the potential role of miRNA dysregulation in cellular homeostasis during HIV-1 infection. Here, TP53 is linked to HIV-1 infection.