,14,42 Previous findings reveal the potential of pharmacological inhibition of METTL3 as an important therapeutic strategy for AML.16, 17, 18,20,21,43 Screening our library of VHL-directed METTL3 degraders against a panel of AML cell lines resulted in the identification of ZW27941. The gene discussed is METTL3; the disease is acute myeloid leukemia.