METTL3 and cancer: ,12 METTL3 plays a critical role in a diversity of diseases, notably cancer, heart failure, viral infection, and type 2 diabetes.13, 14, 15 AML cells exhibit elevated METTL3 protein levels compared with normal hematopoietic progenitors, establishing its significance as an essential gene for cancer cell growth.16, 17, 18 METTL3 down-regulation in AML cells induces cell cycle arrest, inhibits cell growth, accelerates apoptosis, and promotes differentiation.16