Using sex, age, Ang(1-7), ACE2, 25(OH)D, 1α-hydroxylase, 24-hydroxylase, and 25-hydroxylase as independent variables, and the presence of OI as the dependent variable, binary logistic regression (forward LR method) analysis was performed to obtain the final model coefficients. This evidence concerns the gene ACE2 and osteogenesis imperfecta.