In control group boys, ACE2 levels {[2.45 ± 1.30 vs. 1.56 (1.85) pg/ml]} were higher than in OI group boys (z = −2.14, P = 0.045); Ang(1-7) levels in control group boys {[45.06 ± 23.53 vs. 18.48 (25.72) ng/ml]} were also higher than in OI group boys (z = −4.79, P < 0.001) (Figures 3A,B). This evidence concerns the gene ACE2 and osteogenesis imperfecta.