In OI group boys and girls, there were no statistically significant differences in ACE2 levels [1.56 (1.85) vs. 1.16 (1.46) pg/ml] (z = −1.15, P = 0.25) and Ang(1-7) levels [18.48 (25.72) vs. 14.12 (21.94) ng/ml] (z = −1.21, P = 0.23) (Figures 3A,B). Here, ANG is linked to osteogenesis imperfecta.