TRAF3 and myeloid neoplasm: TRAF3 is involved in tumor necrosis factor receptor signaling, regulates B-cell survival, and inhibits PC development through IL-6 receptor signaling inhibition.32, 33, 34 ASXL1 works with the Polycomb Repressive Complex 2 (PRC2) complex to repress gene expression, and ASXL1 mutations result in increased expression of leukemogenic genes in myeloid malignancies.35