Case Report: FAP&lt;sup&gt;+&lt;/sup&gt; fibroblasts and SPP1&lt;sup&gt;+&lt;/sup&gt; macrophages in SMARCA2-deficient while SMARCA4-preserved poorly differentiated lung adenocarcinoma: two case reports and multi-omics analysis. The gene discussed is SPP1; the disease is lung adenocarcinoma.