(n=89), and multiplexed immunohistochemistry (IHC) staining of these two cases to decipher the poor prognosis dependent on the immunosuppressive barrier formed by FAP<sup>+</sup> fibroblasts and SPP1<sup>+</sup> macrophages in the SMARCA2-deficient while SMARCA4-preserved poorly differentiated lung adenocarcinoma (LUAD). Here, SMARCA2 is linked to lung adenocarcinoma.