IL4 and neoplasm: Studies reveal that IL-4 mainly triggers the production of IFN-γ via natural killer (NK) and NKT cells instead of traditional T cells, indicating a complicated interaction between these cytokines, (2) Interferon-gamma (IFN-γ) promotes antigen presentation through MHC II molecules and increases macrophage activation, both of which are essential for mediating anti-tumor immunity.