In addition, in CRC, increased expression of myosin regulatory light chain 9 (MYL9) in CAFs facilitates secretion of CCL2 and TGF-β1, which are linked to recruitment and infiltration of TAMs, resulting in the establishment of an immunosuppressive microenvironment that renders the tumor unresponsive to immunotherapy (56). Here, MYL9 is linked to colorectal carcinoma.