Regarding adaptive immune cells, CD4+ T cells have been reported to induce tumor-infiltrating macrophages to adopt an M1-like tumoricidal phenotype via IFN-γ, and promote the synthesis of nitric oxide (NO) in M1 through inducible nitric oxide synthetase (iNOS), resulting in indirect killing of multiple myeloma (MM) cells (75). The gene discussed is CD4; the disease is neoplasm.