Moreover, osteopontin secreted by myofibroblastic metastasis-associated fibroblasts (myMAFs) promotes an immunosuppressive macrophage phenotype, whereas pharmacological blockade of STAT3 or myMAF-specific genetic depletion of STAT3 restores an anti-tumor immune response and reduces PDAC liver metastasis (17). The gene discussed is SPP1; the disease is neoplasm.