STC1 and cancer: For instance, in lung adenoma cancer, secretion of stanniocalcin-1 (STC1) by CAFs was found to inhibit differentiation and maturation of TAMs through sequestration of glucose regulated protein 94 (GRP94) an autocrine macrophage-differentiation-inducing factor, by binding to its cognate scavenger receptor, thereby hindering the development of cancer (90).