In addition, in CRC, increased expression of myosin regulatory light chain 9 (MYL9) in CAFs facilitates secretion of CCL2 and TGF-β1, which are linked to recruitment and infiltration of TAMs, resulting in the establishment of an immunosuppressive microenvironment that renders the tumor unresponsive to immunotherapy (56). The gene discussed is TGFB1; the disease is neoplasm.