CCL2 and glioblastoma: Another study showed that phytosomal curcumin exerts its therapeutic effect in GBM by inducing the release of monocyte chemoattractant protein-1 (MCP-1, also known as C-C motif chemokine ligand 2 (CCL2)), from TAMs, which in turn recruits activated NK cells to GBM, resulting in anti-tumor effects (21).