In the bone marrow microenvironment of MM, malignant plasma cells release mitochondrial DNA to activate macrophages and promote chemokine-induced upregulation of macrophages via stimulator of interferon genes (STING) signaling; these mtDNA-activated TAMs promote MM progression and retention of MM cells in the pro-tumoral bone marrow microenvironment. This evidence concerns the gene STING1 and Miyoshi myopathy.