SPP1 and cancer: For instance, a study analyzing scRNA-seq data of myeloid cells from 380 samples representing 15 cancer types identified seven TAM subgroups: inhibin beta A (INHBA)+, complement C1q C chain (C1QC)+, interferon-stimulated gene 15 (ISG15)+, NLR Family Pyrin Domain Containing 3 (LNRP3)+, lymphatic vessel endothelial receptor-1 (LYVE1)+, and secreted phosphoprotein 1 (SPP1)+ TAMs (43).