CD8A and neoplasm: In addition, gamma-aminobutyric acid (GABA) secreted by B cells can facilitate the differentiation of monocytes into anti-inflammatory TAMs, which secrete IL-10 and impede CD8 T cell cytotoxicity, and B cell deficiency or targeted inhibition of GABA-producing enzyme augmented anti-tumor responses in a murine model of colon cancer (77).