Research has demonstrated that the serum of individuals infected with COVID-19 contains various autoantibodies, including antinuclear antibodies (ANA), anti-Sjögren’s syndrome A (SSA) antibodies, anti-Ro-52 and anti-Ro-60 antibodies, antiphospholipid antibodies (APL), anti-interferon (IFN)-α and anti-IFN-1 antibodies, anti-interleukin (IL) antibodies, anti-chemokine antibodies, and anti-cardiolipin antibodies (1). This evidence concerns the gene TRIM21 and COVID-19.