TNF and rheumatoid arthritis: We have also observed that normal and RA Classical Monocytes had different TNFR1 and TNFR2 protein expression, as well as a different expression of TNF response genes, and, therefore, different AUCell scores – normal Classical Monocytes had significantly higher TNFR2 protein expression and responded to TNF more prominently compared with the RA Classical Monocytes (Figure 3D).