CD4 and systemic lupus erythematosus: A study has shown that T cell cellular senescence markers (such as CD4+CD57+, CD8+CD57+, CD4+CD28null, and CD8+CD28null) are also significantly higher in SLE patients, showing a significant positive correlation with the level of atherosclerotic markers (cIMT, FMD, and soluble adhesion molecules) (125).