CYP4A11 and Hypertension: The opposing roles of CYP2E1 19-HETE and CYP4A11 20-HETE are apparent from 19-HETE’s antagonism of 20-HETE-induced vascular sensitization and hypertension [97], inhibition of the Na+/K+-ATPase [102,103] and functions to increase volume absorption in renal proximal tubules [102].