CYP4V2 and steatosis: In human patients, the CYP4F12, CYP4F22, and CYP4V2 mRNA levels increase in steatosis and MASH, while the levels of CYP4B1, CYP4X1, and CYPZ1 mRNAs decrease in steatosis and MASH [32] while the mRNA for these genes increases in HCC.