CYP2E1 and Insulin resistance: CYP2E1 contributes to oxidative stress and steatosis in chronic alcohol-exposure models and MASLD [40] by increasing lipid peroxidation and decreasing levels of antioxidants, superoxide dismutase, glutathione peroxidase, and aldehyde dehydrogenase, leading to elevated levels of protein carbonylation, nitration, phosphorylation and glycation that contribute to increased insulin resistance and impaired glucose tolerance [60].