Many issues need to be addressed before determining the roles of the CYP4A11-mediated 20-HETE and CYP2E1-related 19-HETE in steatosis, steatohepatitis, cirrhosis, and HCC, and possible therapeutic targets in the treatment of CLD. This evidence concerns the gene CYP4A11 and congenital secretory chloride diarrhea 1.