reported that in hepatocellular carcinoma, IFNγ− Tc17 cells recruit Tregs via CCL20 overexpression, while also facilitating angiogenesis through IL-17A and mediating immunosuppression via CTLA-4/PD-1 and IL-10R pathways, collectively driving tumor progression and poor prognosis (74). Here, PDCD1 is linked to hepatocellular carcinoma.