To explore the intercellular interactions between tumor and T cells within TME, we applied Ro/e scoring to identify T cell subclusters enriched in the tumor tissues, specifically focusing on CD4_Exhausted, CD8_Teff, CD8_Tc17, Treg_Suppressive, Cycling T cells, CD8_GZMK_ZNF683 and CD8_Exhausted (Figure 5, Supplementary Figure S2D). This evidence concerns the gene CD4 and neoplasm.