Eight genes that were commonly upregulated, including LAYN, CTLA4, CXCR6, ITGAE, SIRPG, ENTPD1, TOX and BATF, all associated with tumor progression or poorer prognosis (49, 51, 55–62) (Figures 3F, Supplementary Table S3). This evidence concerns the gene ITGAE and neoplasm.