Potentially targetable GAs found less frequently in the RETfus+ group included BRCA1, BRAF, FGF12, FGFR1, KEAP1, KMT2D, KRAS, MDM2, MET, NF1, NSD3, PIK3CA, RB1, AND TP53. The presence of HRD, APOBEC and Tobacco gene signatures were also lower in frequencies in the RETFus+ NSCLC cases. The gene discussed is NF1; the disease is non-small cell lung carcinoma.