On the other hand, other germline mutations predispose to chronic liver disease, leading to fibrogenesis, cirrhosis and eventually to HCC, for example, hemochromatosis due to HFE mutations, Wilson disease due to ATP7B mutations, alpha-1 antitrypsin deficiency due to SERPINA1 mutations and tyrosinemia due to FAH mutations (182). The gene discussed is SERPINA1; the disease is hyperinsulinemic hypoglycemia, familial, 4.