NFKB1 and central nervous system cancer: Building on these insights, future research is poised to focus on deciphering the bidirectional relationship between inflammation and oxidative stress, such as the crosstalk between ROS mediated signaling and inflammatory pathways like NF-κB, in the context of glioma progression, as well as developing oxidative therapies that target both the blood-brain barrier to enhance drug delivery and the tumor microenvironment to exploit its redox vulnerabilities.