In 2023, a team knocked down Malat1 RNA expression using gapmer ASOs and found that the levels of the chemokines CXCL1, GM‐CSF, and TNF‐α, which support MDSC recruitment, development, and immune suppression in the TME, were reduced, decreasing the number of PMN‐MDSCs in the tumor [212]. Here, CXCL1 is linked to neoplasm.