HSP90B2P and leishmaniasis: A number of studies have demonstrated that Hsp90inhibitors from Leishmania sp can block parasitegrowth and stress adaptation., Additionally, inhibitorstargeting L. donovaniHsp78 have shownpromising antileishmanial activity, further expanding the potentialof Hsp-targeting therapies for leishmaniasis. Given the essential role of Hsp78 in proteostasis and stressadaptation, its inhibition disrupts parasite survival and virulence,making it a compelling target for therapeutic intervention.