On the other hand, the spatial WM performance of the 3xTg‐AD mice demonstrates a negative correlation with the expression of the GABABR1 receptor in the PFC (r = ‐0.508, p < 0.037) and the GAD67 in the DG of the hippocampus (r = ‐0.555, p < 0.032). The gene discussed is GAD1; the disease is Alzheimer disease.