Periostin, a top upregulated SASP factor, is an ECM remodeling matricellular protein that increases with age in murine ovaries and is known to be implicated in ovarian cancer recurrence, along with its implication in other cancers associated with chronic inflammation (Bons et al. 2023; Dipali et al. 2023; González‐González and Alonso 2018; Huang, Byrd et al. 2023; Tilman et al. The gene discussed is POSTN; the disease is ovarian cancer.