In the univariate analysis, we included age, gender, maximum cardiac dose, complication (hypertension, diabetes mellitus and coronary heart disease), medication history (anthracyclines, targeted drugs, immunosuppressive agents, angiotensin converting enzyme inhibitor/angiotensin receptor blocker, β blockers and statins), smoking history, TnT, NT-proBNP, LVM, LVEF, E/A, E/Em, left atrial pressure and GLS into the logistic regression model, and carried out binary Logistic regression analysis with early RIHD as the dependent variable. Here, NPPB is linked to diabetes mellitus.