In the univariate analysis, we included age, gender, maximum cardiac dose, complication (hypertension, diabetes mellitus and coronary heart disease), medication history (anthracyclines, targeted drugs, immunosuppressive agents, angiotensin converting enzyme inhibitor/angiotensin receptor blocker, β blockers and statins), smoking history, TnT, NT-proBNP, LVM, LVEF, E/A, E/Em, left atrial pressure and GLS into the logistic regression model, and carried out binary Logistic regression analysis with early RIHD as the dependent variable. The gene discussed is NPPB; the disease is coronary artery disorder.