With numbers balanced by treatment allocation groups, the proportion of participants with signs of underlying inflammation (i.e. CRP > 5mg/l) was 20 %; those with prior history of diabetes, heart disease, hypertension and diabetes were 9 %, 15 %, 39 %, respectively, and the proportion that reported joint aches and pains was 64 % (online Supplementary Table S1)(20) suggesting the presence of low-grade inflammation in this otherwise healthy population. Here, CRP is linked to heart disorder.