Meral et al. compared patients with FPLD2 with hypoleptinemia (serum leptin < 7th percentile of normal) versus those with moderate hypoleptinemia (serum leptin in the 7–20th percentiles) and observed that leptin therapy was equally effective in reducing serum and hepatic triglyceride levels without improving hyperglycemia. Here, LEP is linked to Hyperglycemia.