Although data on bariatric surgery in patients with lipodystrophy are scarce, there is evidence that some individuals who underwent Roux-en-Y gastric bypass, particularly those with pathogenic variants in LMNA and PLIN1, or without variants in LMNA and PPARG (suggesting FPLD1), showed significant improvement in metabolic parameters and weight loss. This evidence concerns the gene NOTCH3 and lipodystrophy.