CD4 and HIV infectious disease: In these sense it has been reported that in the acute phase of HIV infection, elevated plasma levels of inflammatory cytokines are associated with a high viral load and can estimate the time at which the CD4+ T-cells count will drop < 350 cells/μL; in this study, PLWHIV showed a CD4+ T-cells count > 400 cells/μL; this could explain that PLWHIV in this study still do not show a significant elevation of most of the evaluated cytokines [63].