CD4 and infection: Regarding our study, even if CXCR4 was not found significantly elevated, probably due to the inclusion of PLWHIV in early stage of infection, a positive correlation between CXCR4 and DR5 expression (p < 0.001) in both CD3+ CD4+ T-cells (r = 0.86; p < 0.001) and CD14+ CD4+ monocytes (r = 0.68; p < 0.005) was found.