CD4 and HIV infectious disease: Additionally, in Fig. 5A and B, it can be seen a negative correlation between time of HIV infection and the expression percentage of CCR5 in CD3+ CD4+ T-cells as well as CD14+ CD4+ monocytes from PLWHIV (r = − 0.73; p < 0.05 and r = − 0.79; p < 0.05); respectively.