The expression of TRAIL DR5 significantly increased in CD3+ CD4+-T cells and CD4+ CD14+ monocytes from PLWHIV; in the same way DR5 was positively correlated with time of infection, with CXCR4 expression and with the significant increase in serum levels of IL-18, making it an interesting target for future treatments and as a marker for HIV disease progression. The gene discussed is TNFRSF10B; the disease is infection.