The objective of this study was to analyze in PLWHIV the effect of HIV infection, on the serum concentration of inflammatory cytokines, as well as effect of the virus on the expression of receptors and ligands of the Fas and TRAIL pathways, the expression of the coreceptors CXCR4, CCR5 and activation markers in CD3+ CD4+ T-cells and CD14+ CD4+ monocytes derived from PLWHIV before ART. This evidence concerns the gene CXCR4 and HIV infectious disease.