In vitro assays have reported an increase in the expression of CD80 and CD86 after exposure to HIV infection [40], Otherwise, in relation to apoptosis mediated by CD80 and CD86 expression, it is known that at least in B cells, CD80 and CD86 regulate the expression of pro-apoptotic as well as Fas and FasL expression and anti-apoptotic molecules; respectively. Here, CD86 is linked to HIV infectious disease.