The HIV infection is characterized by a chronic immune activation and hyperactivation, which increase death ligand expression, favoring CD4+ T-cells depletion The “hyper immune activation” hypothesis in HIV infection suggests that, there is a high rate activation and cell proliferation of CD4+ and CD8+ T-cells, NK cells, and B cells, which is associated with the upregulation of activation markers; consequently, these cells have a decreased life period and become depleted quickly due to activation induced cell death or apoptosis [1, 6]. The gene discussed is CD8A; the disease is HIV infectious disease.