Specifically, the insulin-like growth factor 2 messenger RNA-binding proteins (IGF2BPs), including IGF2BP1, IGF2BP2 and IGF2BP3, among the m6A-binding proteins function as a family of m6A readers that play oncogenic roles in HCC by promoting the accumulation of oncogenic transcripts such as MYC9. Here, IGF2BP2 is linked to hepatocellular carcinoma.