By contrast, the initial HCC detection occurred at 22 weeks in the si-Gas5, mmu-miR-423-3p and si-Smarca4 groups, with significantly fewer mice developing HCCs by 24 weeks: one of five in the si-GAS5 group, three of five in the mmu-miR-423-3p group and two of five in the si-Smarca4 group (Fig. 6a and Supplementary Fig. 16b). This evidence concerns the gene SMARCA4 and hepatocellular carcinoma.