Statistical analysis of tumor cell-intrinsic cGAS and STING expression, co-cultured with CAFs derived from 10 different patients, demonstrated that CAFs significantly reduced cGAS expression in WiDr cells and markedly suppressed STING expression in WiDr, LoVo, and HCT116 cells (Fig. 3C, D). The gene discussed is STING1; the disease is neoplasm.