Regarding the mechanistic insight underlying CAF-mediated suppression of anti-tumor immune responses in CRC, CAFs recruit, differentiate, and activate immune cells involved in the inhibition of anti-tumor immunity, including M2-tumor-associated macrophages (M2-TAMs) and regulatory T cells, while excluding cytotoxic CD8+ T cells in the TME27. Here, CD8A is linked to colorectal carcinoma.