CGAS and colorectal carcinoma: However, treatment with recombinant human TGF-β1 (active form) did not affect cGAS–STING expression levels in WiDr, LoVo, or HCT116 cells (Supplementary Fig. S4), suggesting that TGF-β produced by CAFs might not be involved in the downregulation of cGAS–STING expression in CRC cells.