Based on our IHC analysis of STING in CRC, we have identified four distinct groups within the CRC TME based on differences in STING expression between stromal areas and tumor cells: stromal STINGhigh/tumor cell STINGhigh, stromal STINGhigh/tumor cell STINGlow, stromal STINGlow/tumor cell STINGhigh, and stromal STINGlow/tumor cell STINGlow CRCs (Supplementary Figure S5). The gene discussed is STING1; the disease is neoplasm.