Immunofluorescence staining of renal tissues from DN patients revealed that the expression of CD248 and CCL-5 was mainly associated with eosinophils, with no significant correlation being observed with renal function (Figure 41–R); furthermore, as the degree of eosinophilic infiltration increased, the expression of CD248 and CCL5 also increased. This evidence concerns the gene CD248 and liver dysplastic nodule.