METTL9 and hepatocellular carcinoma: For example, METTL9-mediated methylation of S100A9 suppresses anti-Staphylococcus aureus activity in mouse neutrophils, and methylation of NDUFB3 was suggested to affect cell migration and invasion in metastatic scirrhous gastric cancer, whereas methylation of zinc transporters has been linked to progression of hepatocellular carcinoma (12, 13, 15).