Since then, this SNP and other non-coding TMEM106B SNPs in linkage disequilibrium with rs1990622 have been associated with many neurodegenerative diseases, including FTLD with mutations in the C9ORF72 gene, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), chronic traumatic encephalopathy (CTE), hippocampal sclerosis of aging (HS-Aging), and limbic-predominant age-related TDP-43 encephalopathy (LATE) (1, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26). Here, TMEM106B is linked to amyotrophic lateral sclerosis.