NMT1 and Alzheimer disease: Some evidence loosely ties NMT1 to brain aging and neurodegeneration: the rs4341787 SNP located in the enhancer region of the NMT1 gene modulates AD risk, methylation near the NMT1 locus is altered during aging, and C9ORF72 dipeptide repeats can bind to NMT enzymes (58, 59, 60).