Although we observed a decrease in enzymes such as glucose-6-phosphate isomerase (K01810), 6-phosphofructokinase 1 (K00850), and pyruvate kinase (K00873) between 3 h in vitro and 24 h p.i., the Cwiklinski et al. (2018) (13) study highlighted the dynamic regulation of glycolysis and glycogen metabolism to meet the energy demands associated with early infection. The gene discussed is GPI; the disease is infection.