Additionally, our research highlights three key proteins (Tagln2, Slc25a3, and Pafah1b3) that are differentially abundant in Wistar Han rats and C57BL/6 mice, are affected by STZ-icv in the model that develops cognitive deficits and are also consistently altered in the same direction across human AD cohorts. Here, TAGLN2 is linked to Cognitive impairment.