Based on the identification of this pathway, we selectively extracted data on species-specific brain expression of individual proteins from the IGF-1 protein interaction network within STRING (Fig. 4e), observing differences that may provide valuable insights not only for the STZ-icv model but also for other rodent models of AD, given the critical role of insulin signaling in disease etiopathogenesis. Here, IGF1 is linked to Alzheimer disease.