Bag5 appears to have a protective role in Alzheimer’s disease, as its levels are increased in the brains of AD mice, while its silencing has been shown to exacerbate the toxic effects of amyloid-β and promote the production of reactive oxygen species (Guo et al. 2015; Wang et al. 2014), which are key contributors to AD (Homolak and Çakatay 2022). Here, BAG5 is linked to early-onset autosomal dominant Alzheimer disease.