Given that mouse Rp1l1 interacts with Rp117 and that pathogenic variants of human RP1 [MIM: 603937] are well-known causes of autosomal dominant retinitis pigmentosa [RP] [MIM: 268000]),36,37 we explored the interaction between human RP1L1 and RP1. The gene discussed is RP1L1; the disease is retinitis pigmentosa 1.