Additionally, we investigated the impact of G9a inhibition with UNC0642 and selective CB1R (ACEA) and/or CB2R (JWH133) agonists on cognitive decline and neuroinflammation in the SAMP8, a late-onset Alzheimer's disease (LOAD) mouse model [[48], [49], [50]]. The gene discussed is EHMT2; the disease is Alzheimer disease.