Proteins encoded by EPHB4 were targeted by 11 drugs (DB01254, DB07251, DB07253, DB07256, DB07254, DB11973, DB07249, DB07250, DB07252, DB07255, DB12010), suggesting that these pharmacological interventions may facilitate the treatment of endometriosis through the modulation of EPHB4. RSPO3, CD109, SAA1, SAA2, FSHB, and SEZ6L2 had no available corresponding drugs, indicating that these proteins are potential targets for drug discovery. The gene discussed is RSPO3; the disease is endometriosis.