In GBM, an increased H3 K9 lactylation has been observed in recurrent and TMZ-resistant cells, where it may promote TMZ resistance by upregulating LUC7 like 2 (LUC7L2), a pre-mRNA splicing factor that suppresses MutL homolog 1 (MLH1) and impairs mismatch repair [240]. Here, MLH1 is linked to glioblastoma.