Recent research suggests that G9a may promote GSCs stemness and an immunosuppressive tumor microenvironment by catalyzing H3 K9 me2 at the promoter of F-box and WD repeat domain-containing 7 (FBXW7), repressing its transcription and activating Notch signaling, which can lead to MHC-I suppression and PD-L1 upregulation. Here, EHMT2 is linked to neoplasm.