MGMT and glioblastoma: Additionally, long non-coding(lnc) TALC (temozolomide-associated lncRNA in glioblastoma recurrence) promotes TMZ resistance by activating the c-Met/signal transducer and activator of transcription 3(STAT3)/p300 axis, which increases H3 acetylation at the MGMT promoter, thereby enhancing MGMT expression [42].