EGFR and glioblastoma: Studies have suggested that CBX3 may directly repress transcription of Parkin RBR E3 ubiquitin protein ligase (PARK2) and STIP1 homology and U-box containing protein 1 (STUB1) via its chromodomain, reducing ubiquitination and stabilizing EGFR protein levels, thereby promoting GBM initiation and progression [234].