Moreover, elevated HDAC1 has been shown to promote deacetylation of H3 K27ac at the solute carrier family 30 member 3 (SLC30A3) locus, which is associated with repression of its expression and may facilitate GBM progression through the p38 mitogen-activated protein kinase (MAPK) signaling pathway. The gene discussed is HDAC1; the disease is glioblastoma.