In GBM, the low expression of Tip60 inversely correlates with matrix metalloproteinase 14 (MT1-MMP) levels via modulation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway and has been shown to inhibit the invasive capacity of GBM cells [50, 51]. The gene discussed is KAT5; the disease is glioblastoma.