Panobinostat (LBH589) has been shown to disrupt the heat shock protein 90 (Hsp90)/HDAC6 complex and induce degradation of hypoxia-inducible factor 1α (HIF-1α), resulting in decreased vascular endothelial growth factor (VEGF) expression and subsequent inhibition of tumor angiogenesis and growth [126]. This evidence concerns the gene HIF1A and neoplasm.