The KDM4 (JMJD2) family, comprising KDM4A, KDM4B, and KDM4C, is reported to be overexpressed in GBM and to mediate demethylation of H3 K9, H3 K36, and histone H1.4 lysine 26 [215]. The gene discussed is KDM4C; the disease is glioblastoma.