Immunostaining for EZR further revealed localization at the apical membrane (adjacent to the CSF) of epithelial cells in WT mice but decreased and redistributed expression in APP/PS1 mice, and quantification of EZR expression from the apical to basal membrane showed a more even distribution in APP/PS1 mice, indicating a loss of epithelial polarity in the ChP at the early stages of AD (Fig. 3G-I). The gene discussed is APP; the disease is Alzheimer disease.