TF and cancer: Since iron may be one of the causes of oxidative stress in the cell, in addition to being an essential nutrient, and a cofactor for enzymes involved in DNA replication and energy production, the need for iron increases in the case of rapidly dividing cells, and it is important to study the variability of its metabolism in cancer cases, especially the variations of proteins related to its transfer to the cells, transferrin as the major transporter and lipocalin 2 [6].