Experiments using an EC xenograft model demonstrated that the oncogenic role of KLF13 was mediated through regulation of GPIHBP1, as tumor size (Fig. 7I), tumor volume (Fig. 7J) and tumor weight (Fig. 7K) were all greatly reduced in KLF13 + shGPIHBP1 group relative to those in KLF13 group. Here, GPIHBP1 is linked to neoplasm.