Two set cell experiments, with “KLF13 knockdown + GPIHBP1 overexpression” and “KLF13 overexpression + GPIHBP1 knockdown”, demonstrated the role of KLF13 in promoting EC cell proliferation, migration, and lipid regulation recovery to normal levels through suppression of GPIHBP1, and increased tumour size in vivo. Here, GPIHBP1 is linked to neoplasm.