INCR1, an IFNγ-induced lncRNA encoded across the CD273/PDCD1LG2 locus and transcribed in the anti-sense direction, was recently shown to control IFNγ induction of JAK2, STAT1, PD-L1, PD-L2, IDO1, and likely other JAK/STAT-driven immunoregulatory genes in glioblastoma, melanoma, and breast adenocarcinoma (18). The gene discussed is CD274; the disease is glioblastoma.