DICER1 and adenoma: Interestingly, a study that profiled the miRNA and mRNA transcriptomes of DICER1-associated thyroid tumors observed that malignant tumors (carcinomas) had an increase in 3p miRNAs, whereas this did not occur in adenomas and this fact could be at least in part explained by an increased expression of DICER1 mRNA and protein levels as observed in carcinomas [43].