SLAMF3 has been reported to inhibit macrophage phagocytosis by activating SHP‐1/2 phosphatase activity and suppressing the downstream phagocytosis‐related signaling molecule mTORC1 in macrophages.[42] We isolated macrophages from mouse liver metastases to investigate whether CRC inhibits macrophage phagocytosis through the SHP‐1/2/mTORC1 signaling pathway (Figure 5K). The gene discussed is LY9; the disease is colorectal carcinoma.