Notably, RUNX1 has been most extensively studied for its oncogenic role in hematological malignancies.[51, 52] Similarly, SLAMF3 has also been reported to be closely associated with the development and progression of hematologic tumors.[19, 42] These findings raise the intriguing possibility that CRC cells may acquire, to some extent, characteristics reminiscent of hematopoietic cells. The gene discussed is LY9; the disease is hematologic disorder.