SLAMF3 is typically expressed on hematopoietic cells and recognizes itself as a self‐ligand to regulate the function of immune cells.[24] We found that RUNX1 transcriptionally upregulated SLAMF3 expression in CRC cells, thereby inhibiting M1 macrophage polarization and phagocytosis of CRC cells. The gene discussed is LY9; the disease is colorectal carcinoma.