IRE1α‐dependent decay (RIDD) mainly targets ER‐bound mRNAs, and seems to require a typical stem‐loop endo‐motif, the XBP1u‐like consensus loop sequence CNG|CAGN, supported by stable stem.[11] Enhanced IRE1α signaling has been observed in AD patient neurons containing abnormally phosphorylated Tau.[12] However, the underlying mechanism of IRE1 α‐ dependent regulates the occurrence and development of AD is still unclear, and further in‐depth exploration is needed. The gene discussed is MAPT; the disease is Alzheimer disease.