Mutation of the mouse ortholog Listerin leads to neurodegeneration, which suggested that Listern has a crucial function for in this process.[15] One large‐scale deep multilayer analysis of brain tissue from AD patients using TMT‐MS‐based quantitative proteomics showed differential expression of Listerin in AD patients compared to healthy individuals (p = 0.000804774).[17] We further calculated the mean expression of Listerin and found that the expression of Listerin was lower in the brain tissue of AD patients than in healthy control individuals (Figure S1A, Supporting Information). Here, LTN1 is linked to Alzheimer disease.