LPS‐induced systemic inflammation and brain inflammation affect the pathological process of AD in various ways.[20] In previous studies, an animal model of memory loss similar to Alzheimer's disease was established by injecting LPS into the brain or intraperitoneal cavity of mice.[21] To evaluate the role of Listerin‐mediated microglial inflammation in AD, we next performed a systemic inflammation model in which LPS was injected into the bilateral entorhinal cortices of the Listerinfl/fl and Listerinfl/flCx3cr1 Cre mice. This evidence concerns the gene LTN1 and Alzheimer disease.