Up‐regulated TLR4 in microglial cells can lead to the hyperactivation of neuroinflammatory, neuronal degeneration, and further aggravate the progression of AD.[23] In our mouse models, we found increased protein expression levels of TLR4 in Listerinfl/flCx3cr1 Cre mice than that in Listerinfl/fl mice with Aβ or LPS stimulation (Figure 1J; Figure S2G, Supporting Information), indicating that Listerin may target TLR4 to participate in brain inflammation. Here, TLR4 is linked to Alzheimer disease.