et al. reported that PUM1 interacted with the 3′‐untranslated region of TLR4 and suppressed the translation of TLR4 mRNA to suppress osteoarthritis.[36] Moreover, HNRNPA2B1 mediates the epigenetic regulation of TLR4 RNA by m6A modification, which promotes multiple myeloma proliferation and inhibits apoptosis.[37] Our study found that Listerin targets TLR4 mRNA to regulate brain inflammation in AD. Here, PUM1 is linked to osteoarthritis.